Results
| PMID | 11937115 |
| Gene Name | KIR3DL1 |
| Condition | Endometriosis (Pelvic) |
| Association |
Associated |
| Population size | 54 |
| Population details | 54 (28 women with endometriosis, 26 women without endometriosis) |
| Sex | Female |
| Associated genes | ICAM-1, KIR |
| Other associated phenotypes |
Pelvic endometriosis |
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Fertil Steril. 2002 Apr;77(4):679-83. Maeda, Nagamasa| Izumiya, Chiaki| Oguri, Hiroyoshi| Kusume, Tomoaki| Yamamoto, Yorito| Fukaya, Takao Department of Obstetrics and Gynecology, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, Japan. maedan@med.kochi-ms.ac.jp OBJECTIVE: To investigate host immunologic response to endometriosis in terms of intercellular adhesion molecule (ICAM)-1 expression by macrophages and killer cell inhibitory receptor (KIR) expression by natural killer (NK) cells. DESIGN: Case-control study of immunologic markers. SETTING: University hospital. PATIENT(S): Twenty-eight Japanese women with endometriosis. Control subjects were 26 women without endometriosis. Diagnoses were made at laparoscopy. INTERVENTION(S): Venipuncture and laparoscopic peritoneal fluid collection. MAIN OUTCOME MEASURE(S): ICAM-1 expression by macrophages and KIR expression by NK cells, measured by flow cytometry. RESULT(S): In women with endometriosis, expression of ICAM-1 by peritoneal macrophages was significantly lower and expression of KIR by NK cells in peritoneal fluid and peripheral blood was significantly higher than in control subjects. CONCLUSION(S): Properties of macrophages and NK cells in women with endometriosis promote immunotolerance to implanted tissue in the peritoneal environment. Increased KIR(+)NK cells in peripheral blood may represent a risk factor for endometriosis. Mesh Terms: Adult| Antibodies, Monoclonal| Ascitic Fluid/cytology| B-Lymphocytes| Case-Control Studies| Endometriosis/*immunology/metabolism| Female| Flow Cytometry| Humans| *Immune Tolerance| Intercellular Adhesion Molecule-1/*analysis| Killer Cells, Natu |
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